Background: Chronic inflammatory airway disease (CIAD) has emerged as independent risk factor for cardiovascular\nmortality and ischemic stroke but the impact of co-existing CIAD in patients with ischemic stroke is less clear.\nMethods: We retrospectively analyzed 1013 patients with acute ischemic stroke who were consecutively admitted to\nthe Department of Neurology, CharitÃ?© - UniversitÃ?¤tsmedizin Berlin, Germany within one year. Mean follow-up was\n80 months (IQR 32ââ?¬â??85 months). Using multivariable regression models we analyzed the impact of CIAD (defined as\nchronic obstructive pulmonary disease or asthma bronchiale) on stroke severity and outcome.\nResults: Co-existing CIAD was evident in 7.1 % (n = 72) of all patients with acute ischemic stroke. Baseline characteristics\nof stroke patients with CIAD did not differ significantly from ischemic stroke patients without CIAD. Age (OR 1.17 [95 % CI\n1.03-1.37] per decade), atrial fibrillation (OR 3.43 [95 % CI 2.47-4.78]) and coronary artery disease (OR 1.51 [95 % CI\n1.07ââ?¬â??2.14]) but not a history of CIAD (p = 0.30) were associated with severe stroke (NIHSSââ?°Â¥11) on hospital\nadmission. Age (HR 1.70 [95 % CI 1.53-1.87] per decade), peripheral artery disease (HR 1.91 [95 % CI 1.35-2.7]),\nstroke severity at hospital admission (NIHSS per point HR 1.08 [95 % CI 1.06-1.10]), and history of CIAD (HR 1.43\n[95 % CI 1.02-2.00]) were independently associated with mortality during long-term follow-up. However, CIAD was\nnot significantly associated with short-term mortality after stroke.\nConclusion: Co-existing CIAD showed no significant association with stroke severity at hospital admission and\nearly mortality after ischemic stroke. CIAD was negatively associated with long-term survival after ischemic stroke.
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